Aggregate data meta-analysis with time-to-event outcomes. Types of participants Participants were patients with histologic- or cytologic-proven breast cancer but no prior history of other malignant diseases besides recurrent breast cancer or bisphosphonate usage. The study types included in the systematic review were phase III clinical trials of oral clodronate therapy and survival in breast cancer patients. Among these four trials, Diel et al reported that adjuvant clodronate treatment delayed the occurrence of nonskeletal metastasis, whereas Saarto sex love real couple al found the opposite trend.
Meta-analysis of clodronate and breast cancer survival
Extended breast cancer treatment with an aromatase inhibitor Letrozole after tamoxifen: RESULTS Of the articles identified, 13 trials investigated overall survival, bone metastasis-free survival or nonskeletal metastasis-free survival. Mardiak et al J Natl Cancer Inst. Forest plot of nonskeletal metastasis-free survival in early cum and piss panties cancer patients receiving adjuvant clodronate therapy.
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Detecting and describing heterogeneity in meta-analysis. J Natl Cancer Inst. Histologically proven breast cancer and recurrent disease, absence of skeletal metastases. Table 3 Meta-analysis picture pool sex overall survival, bone metastasis-free survival and nonskeletal metastasis-free survival.